- 1 CBD Treatment for Cancer
- 2 CBD’s interaction with Endocannabinoid’s receptors
- 3 CBD For Specific Cancer Treatment
- 4 Use of CBD during chemotherapy
- 5 CBD treatment for dogs with cancer (and other pets)
- 6 Conclusion
- 7 CBD for Cancer – Customer Reviews
Cancer has been one of the most serious health conditions plaguing humans and animals for a long time. Thankfully, there are several alternative treatments and supplements that can help counter the condition. According to studies, CBD for cancer treatment is one of the most outstanding options for alleviating symptoms (without any uncomfortable side effects) that you can count on.
CBD Treatment for Cancer
A compound extracted from the hemp plant, cannabidiol (CBD) has shown crucial in the fight against cancer and tumors. The cannabis plant from which CBD is extracted has seen a fair share of use in different societies over the centuries. From the traditional Chinese medicine to Greek lore, India’s Ayurvedic practice and more, this herb has established a foothold in the medical world. CBD oil for cancer continues to come to the aid of humanity. Mostly, this medicine proves crucial thanks to its interaction with the endocannabinoid system. This way, it can help maintain the body’s balance and so much more.
CBD’s interaction with Endocannabinoid’s receptors
This system comprises two primary receptors, cannabinoid 1 (CB1) and cannabinoid 2 (CB2). According to studies, Cannabinoid 1 receptors are in the brain as well as the central nervous system. The CB 2, on the other end, is available in the spleen, immunity system and other such structures1.
These receptors will respond differently according to the type of cannabinoid. For instance, THC has more affinity to CB1, but it comes in as an agonist for the two. As such, it binds with and activates both cannabinoid types.
On the other end, CBD acts indirectly against the cannabinoid agonists rather than binding directly with them. Hence, CBD gets imperfectly within them and blocks THC as well as other chemicals from binding with the cannabinoids.
Another essential thing done by CBD is interacting with several other receptors in the body. These include 5-HT1A receptors, usually linked to the vanilloid receptor TRPV1 and serotonin2. Most importantly, these receptors come in as an ion channel. Essentially, CBD helps with different functions, from the body’s homeostasis to environmental functions.
CBD For Specific Cancer Treatment
When it comes to the use of CBD for cancer treatment, this substance has proven to be essential for taking on diverse types of cancers. It can be used for Lung cancer, Leukemia, Skin cancer, tumors, or other cancers. CBD can help control the spreading of the condition, reducing it all together.
This comes down to the antitumor efficiency from cannabinoids thanks to cannabidiol effects on carcinoma on the human breast. CBD coordinates communication between apoptosis and autophagy, hence enhancing programmed cell death in breast cancer cells. According to another study, CBD helps in many other ways of reducing and eradicating breast cancer4.
CBD shows great potential in combating bladder cancer. The activation of TRPV22, for instance, triggers apoptotic cell death in the T24 bladder cancer cells in humans5. Besides, studies show that CBD has the potential to treat lymphoblastic diseases. These include lymphoma and leukemia6. CBD has proved capable of promoting suicide in lymphoma cancer cells, a situation known as apoptosis. In essence, CBD relates to CB2 receptors to decrease the risk of cancerous cells forming7.
Scientific reviews have shown that CBD can prevent colon cancer8. According to the study, CBD has the potential to reduce the development of some carcinogenic factors normally found in colorectal cancer patients. CBD may help reduce abnormal glands in the rectum and colon, the so-called aberrant crypt foci (ACF). The study also states that CBD is able to reduce tumour formation and the number of polyps.
A study by the Journal Pharmacology and Experimental Therapeutics9 is investigating whether CBD inhibits the growth of brain tumour cells. In the study, mice were given a dose of 0.5mg and the growth of implanted human U87 glioma cells was observed. The result was significant antitumor activity caused by cannabidiol.
In February 2019, a case study in which a patient treated an adenocarcinoma of his lung with CBD, attracted attention due to the amazing achieved results10. The tumor in the lung decreased significantly. An earlier study gives indications of how this effect occurs. The role of the COX-2 and PPAR-γ receptors in CBD-induced apoptosis (“suicide program” of biological cells) of lung cancer cells was investigated in more detail11.
Use of CBD during chemotherapy
An article published in 2013 in the journal Carcinogenesis12 describes that CBD makes glioblastoma, the most common malignant brain tumour in adults, more susceptible to chemotherapy. CBD increases TRPV2 activity, which in turn enhances glioma cells’ ability to absorb chemotherapeutic agents. At the same time, there was no effect on the body’s normal astrocytes.
A year later, another study published in the British Journal of Pharmacology concluded that CBD counteracts neuropathic pain without adversely affecting nervous system function or the effectiveness of chemotherapy13.
One of the most important tasks of CBD oil in cancer treatment could be the possible alleviation of side effects of chemotherapy. CBD could minimize undesirable side effects of chemotherapy such as nausea, chronic pain and vomiting. FDA-approved synthetic cannabinoids have already proven helpful in treatment.
In general, orally administered synthetic cannabinoids such as dronabinol14 and nabilone15 have shown dominance over dopamine receptor antagonists. This performance makes them indispensable in preventing CINV.
CBD treatment for dogs with cancer (and other pets)
Research shows that CBD treatment for cancer not only works in humans but also for pets16. Dogs can suffer from different types of cancers. These include skin cancer, which is quite common in dogs. Other types of cancer commonly found in dogs include mammary gland cancer for female dogs, as well as head and neck cancer. Dogs also usually fall victim to mouth cancers, which needs swift action.
Thankfully, CBD has proved to treat cancer in dogs and other pets. Research shows that just like in humans, CBD helps in managing the cancer symptoms. What’s more, it can help deal with some side effects that come with alternative cancer treatment. Preliminary studies also point to CBD’s ability to fight development as well as the spread of some types of tumors.
To do this, CBD stimulates the endocannabinoid system. It then helps in producing even more benefits that can come out of this system. Notably, pets will struggle with the side effects of chemotherapy as much as humans do. CBD has shown the capability of dealing with such gastrointestinal symptoms as nausea and vomiting, common in humans and pets as well. As such, it can indirectly help pets and humans regain appetite that could be lost from cancer treatment. Not forgetting, CBD also proves crucial for inflammation and pain, which can usually result from cancer.
According to the studies, the extract with CBD showed clear anti-tumor effects. It also acted upon the effects of a chemical used in inducing cancer in biological research – azoxymethane. In another study in 2013, CBD also showed the capability of slowing the development of tumors in the brain. Researchers in the Department of Experimental Medicine at the University of Camerino in Italy conducted the study. At the study, CBD also proved to slow the growth of cancer cells and weakening existing ones. This gave chemotherapeutic drugs an edge over the cancerous cells. Similar CBD performance has also come up in studies on other types of cancer. These include bladder cancer, leukemia, lymphoma and many more. For more information about using CBD for your dog, see the video below. You can also read our post about CBD for Pets.
There have been numerous studies of CBD oil for cancer. In 1975, researchers looked into cannabis as an ideal drug for cancer treatment. Despite legal restrictions, the medical industry has studied and discovered exciting evidence of the herb’s effect on cancer patients. One of the outstanding aspects of CBD is that it doesn’t initiate psychoactive effects on patients. This makes it stand out from other cannabinoids from the same plant.
According to preliminary research, CBD for cancer treatment targets the condition in several stages. Among the things that research has shown that CBD can do, includes triggering cell death. It also helps prevent the migration of cancer cells. Further, it contains angiogenesis properties. This helps it block any formation of new blood cells. Hence, it can slow down the spread of any cancer cells. Above all, it reduces cancer invasiveness.
CBD for Cancer – Customer Reviews
Read about the experience people have had using Nordic Oil products for treating cancer*
I’ve bought it twice already for my father…
I have already ordered it 2x for my father. He has kidney cancer and was very depressed during the first treatment cycle and had no appetite. First, we started with 5% as a test, which worked well. He will soon start taking the 10% with curcumin. I am curious about how he will react to it. Delivery goes fast, customer service top. Always helpful. Many thanks to the Nordic Oil team
Delivery’s really fast.
“I take the capsules preventively because I had breast and skin cancer. Stress doesn’t get to me as much, as without the capsules! They do me good, I feel great!”
*Nordic Oil’s products are available in a number of countries, therefore the reviews we receive are in many different languages. The customer reviews within this article have been translated for the convenience of our English speaking readers.
- Bisogno, Tiziana, and Vincenzo Di Marzo. „Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders.“ CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 9.5 (2010): 564-573.
- Linge, Raquel, et al. „Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors.“ Neuropharmacology 103 (2016): 16-26.
- Ligresti, A., Moriello, A., Starowicz, K., Matias, I., Pisanti, S., De Petrocellis, L., Laezza, C., Portella, G., Bifulco, M. and Di Marzo, V. (2006). Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma. Journal of Pharmacology and Experimental Therapeutics, 318(3), pp.1375-1387.
- Shrivastava, Ashutosh, et al. „Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.“ Molecular cancer therapeutics 10.7 (2011): 1161-1172
- Yamada, Takahiro, et al. „TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer.“ Urology 76.2 (2010): 509-e1.
- Massi, Paola, et al. „Cannabidiol as potential anticancer drug.“ British journal of clinical pharmacology 75.2 (2013): 303-312.
- Aviello, Gabriella, et al. „Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.“ Journal of molecular medicine 90.8 (2012): 925-934.
- Massi, Paola, et al. „Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.“ Journal of Pharmacology and Experimental Therapeutics 308.3 (2004): 838-845
- ulé-Suso, Josep, et al. „Striking lung cancer response to self-administration of cannabidiol: A case report and literature review.“ SAGE open medical case reports 7 (2019): 2050313X19832160.
- Ramer, Robert, et al. „COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.“ Molecular Cancer Therapeutics 12.1 (2013): 69-82
- Nabissi, Massimo, et al. „Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.“ Carcinogenesis 34.1 (2012): 48-57.
- Ward, Sara Jane, et al. „Cannabidiol inhibits paclitaxel‐induced neuropathic pain through 5‐HT1A receptors without diminishing nervous system function or chemotherapy efficacy.“ British journal of pharmacology 171.3 (2014): 636-645
- Meiri, Eyal, et al. „Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.“ Current medical research and opinion 23.3 (2007): 533-543.
- Ware, Mark A., Paul Daeninck, and Vincent Maida. „A review of nabilone in the treatment of chemotherapy-induced nausea and vomiting.“ Therapeutics and clinical risk management 4.1 (2008): 99.
- Samara, E. M. I. L., M. E. I. R. Bialer, and R. A. P. H. A. E. L. Mechoulam. „Pharmacokinetics of cannabidiol in dogs.“ Drug metabolism and disposition 16.3 (1988): 469-472.