CBD and Sitagliptin (e.g. Januvia, Xelevia)

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Understanding CBD and Sitagliptin

In recent years, cannabidiol (CBD), a compound found in cannabis plants, has gained popularity for its potential therapeutic benefits. However, it's important to understand how CBD interacts with other medications before incorporating it into your regimen, especially if you're taking prescription drugs like Sitagliptin. Sitagliptin, commonly known by its brand names Januvia in the US, Xelevia in Europe, and Januvia, Tesavel, or Xelevia in other parts of the world, is a medication primarily used to manage type 2 diabetes.

How CBD Works in the Body

CBD is a non-psychoactive compound that interacts with the endocannabinoid system (ECS) in the body. The ECS regulates various bodily functions such as mood, sleep, appetite, and pain. CBD is thought to enhance the function of the ECS, providing potential benefits like pain relief, reduced anxiety, and improved sleep.

How Sitagliptin Works in the Body

Sitagliptin works by regulating the levels of insulin your body produces after eating. It is part of a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. These drugs help to increase the levels of insulin produced by your pancreas and decrease the amount of sugar made by your liver.

Interactions Between CBD and Sitagliptin

While CBD has been found to be generally safe and well-tolerated, it can interact with other medications, potentially altering their effectiveness or causing side effects. This is because CBD is metabolized by enzymes in the liver that also metabolize many other drugs, including Sitagliptin.

Studies on the interaction between CBD and Sitagliptin are limited. However, some research suggests that CBD may inhibit the enzyme system in the liver responsible for the breakdown of Sitagliptin. This could potentially lead to higher levels of Sitagliptin in the body, which may increase the risk of its side effects.

It's important to note that everyone's body responds differently to medications and supplements. Therefore, the interaction between CBD and Sitagliptin may vary from person to person.

Consulting Your Doctor

Before starting CBD or any new supplement, it's crucial to consult your healthcare provider, especially if you're taking other medications like Sitagliptin. Your doctor can provide personalized advice based on your health history and current medications.


While CBD offers potential therapeutic benefits, it's important to understand its interactions with other medications, like Sitagliptin. Current research suggests that CBD may affect how Sitagliptin is metabolized in the body, potentially increasing the risk of side effects. However, individual responses can vary, and more research is needed. Always consult your healthcare provider before starting CBD or any new supplement, especially if you're taking other medications.

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