CBD and Oral Contraceptives (e.g. Ortho Tri-Cyclen, Valette, Diane-35, Yasminelle)

medication pills

Understanding CBD and Its Impact on the Body

Cannabidiol, commonly known as CBD, is a naturally occurring compound found in the cannabis plant. Unlike THC (Tetrahydrocannabinol), another compound found in the same plant, CBD is not psychoactive, meaning it does not produce a "high".

CBD works within the body by interacting with the endocannabinoid system (ECS), a complex cell-signaling system that plays a role in regulating a range of functions and processes, including sleep, mood, appetite, and immune response.

How Oral Contraceptives Work

Oral contraceptives, also known as birth control pills, contain hormones that prevent ovulation. These hormones also cause changes in the cervical mucus and uterine lining, making it harder for sperm to reach the uterus and for a fertilized egg to attach to the uterus.

Popular brands of oral contraceptives include Ortho Tri-Cyclen, Valette, Diane-35, Yasminelle. These brands are available globally, and their active ingredients are ethinyl estradiol and progestin. Ethinyl estradiol is a synthetic version of estrogen, while progestin is a synthetic form of progesterone.

Interactions Between CBD and Oral Contraceptives

As CBD has gained popularity, concerns have been raised about potential interactions with other medications, including oral contraceptives. The main concern is that CBD could affect the way the body metabolizes these medications, potentially altering their effectiveness.

Research suggests that CBD can inhibit an enzyme known as cytochrome P450 complex. This enzyme is responsible for metabolizing certain drugs, including some types of oral contraceptives. If CBD inhibits this enzyme, it could potentially lead to higher levels of these contraceptives in the bloodstream, which could increase their side effects.

However, it's important to note that this interaction is not yet fully understood, and more research is needed to determine the extent and implications of this potential interaction.

Side Effects and Risks

While CBD is generally considered safe, it can cause side effects in some people. These may include fatigue, diarrhea, and changes in appetite and weight. Additionally, it's possible that CBD could interact with other medications, including oral contraceptives, as mentioned above.

Oral contraceptives can also have side effects, including nausea, breast tenderness, and changes in menstrual bleeding. If CBD does indeed affect the metabolism of these drugs, it could potentially exacerbate these side effects.

Consulting Your Doctor

It's crucial to consult with a healthcare provider before starting any new supplement regimen, including CBD, especially if you're already taking other medications. Your doctor can provide personalized advice based on your specific situation and help monitor for potential interactions and side effects.


While CBD has many potential health benefits, it's essential to be aware of potential interactions with other medications, including oral contraceptives. While more research is needed to fully understand these interactions, it's always best to consult with a healthcare provider before starting any new supplement, including CBD.

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