CBD and Naproxen (e.g. Aleve, Naprosyn, Proxen, Naprux)

medication pills

Understanding CBD and Naproxen

With the increasing popularity of Cannabidiol (CBD) as a natural supplement, many people are interested in how it might interact with their current medications. One such medication is Naproxen, which is commonly known under various brand names worldwide. This article aims to provide an unbiased view of the potential interactions between CBD and Naproxen, a common nonsteroidal anti-inflammatory drug (NSAID).

Common Brand Names of Naproxen

Naproxen is a popular NSAID used to relieve pain, inflammation, and fever. It is available in many countries under various brand names. Some of the most common include:

  • Aleve - widely available in the United States and Canada.
  • Naprosyn - common in the United States, Canada, United Kingdom, and Australia.
  • Proxen - available mainly in Australia and some European countries.
  • Naprux - commonly used in Latin American countries.

How CBD and Naproxen Work in the Body

CBD is a natural compound derived from the Cannabis Sativa plant. It works by interacting with the body's endocannabinoid system (ECS), which plays a crucial role in regulating various bodily functions, including pain, mood, and sleep.

On the other hand, Naproxen works by reducing the production of prostaglandins, substances in the body that cause inflammation and pain. It does this by inhibiting enzymes called cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).

Potential Interactions Between CBD and Naproxen

Research into the interactions between CBD and other drugs is still in its early stages. However, studies suggest that CBD can affect the way your body processes certain drugs, including Naproxen. This is because CBD can inhibit cytochrome P450 enzymes, a group of liver enzymes responsible for drug metabolism.

This interaction means that taking CBD and Naproxen together could potentially increase the effects and side effects of Naproxen. This could lead to an increased risk of gastrointestinal problems, including stomach ulcers and bleeding, which are common side effects of NSAIDs.

It's also worth noting that both CBD and Naproxen can potentially cause liver damage. Therefore, combining these substances may increase this risk.

Consulting a Doctor

Given the potential interactions and risks, it's essential to consult a healthcare provider before starting to use CBD, especially if you are already taking medications like Naproxen. Your doctor can provide personalized advice based on your health history and current medications.


In conclusion, while CBD has many potential health benefits, it can interact with certain medications, including Naproxen. This interaction can potentially increase the effects and side effects of Naproxen. Therefore, it's important to consult a healthcare provider before starting to use CBD if you're already on medications. Remember, your health and safety should always come first.

Back to blog

Leave a comment

Please note, comments need to be approved before they are published.