CBD and Montelukast (e.g. Singulair, Montelukast-ratiopharm)

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Understanding CBD and Montelukast

When it comes to managing health conditions, it's essential to understand the potential interactions between different medications. In this article, we will explore the relationship between Cannabidiol (CBD) and Montelukast, a commonly prescribed medication. It's important to note that before starting any new supplement or medication, including CBD, always consult with your healthcare provider.

What is CBD?

CBD, or cannabidiol, is a compound derived from the cannabis plant. Unlike its cousin THC, CBD is non-psychoactive, meaning it doesn't produce the "high" associated with cannabis. It's widely used for its purported health benefits, including relief from pain, anxiety, and inflammation.

CBD works by interacting with the body's endocannabinoid system (ECS). The ECS is involved in regulating a variety of functions including sleep, appetite, pain and immune system response. CBD is thought to encourage the body to produce more of its own endocannabinoids, which may help reduce pain, inflammation, and anxiety.

What is Montelukast?

Montelukast, commonly known by the brand name Singulair in the United States or Montelukast-ratiopharm in parts of Europe, is a medication primarily used to manage asthma and seasonal allergies. It works by blocking leukotrienes, substances in your body that cause inflammation and constriction in your lungs and tightening of the muscles around your airways.

Interactions Between CBD and Montelukast

Currently, there is limited research available on the potential interactions between CBD and Montelukast. However, both substances are metabolized by the liver, specifically through the cytochrome P450 enzyme system. This system is responsible for breaking down and removing toxins from the body.

Because CBD can inhibit this enzyme system, it may affect how the body processes Montelukast. This could potentially increase the concentration of Montelukast in the body, leading to an increased risk of side effects such as headaches, dizziness, and gastrointestinal issues.

Considerations Before Combining CBD and Montelukast

Given the potential interaction between CBD and Montelukast, it's crucial to consult with a healthcare provider before combining these substances. Your doctor can provide personalized advice based on your current health status, other medications you're taking, and your individual response to these substances.


In conclusion, while CBD and Montelukast are used to manage different health conditions, their potential interaction should not be overlooked. Both substances are processed by the same enzyme system in the liver, and combining them could potentially lead to increased side effects. Therefore, it's crucial to consult with a healthcare provider before starting any new supplement or medication, including CBD.

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