CBD and Metformin (e.g. Glucophage, Metformin-ratiopharm, Metformax)

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Understanding CBD and Metformin

Before we delve into the interaction between CBD and Metformin, it is crucial to understand what these substances are and how they function within the body.

What is CBD?

Cannabidiol (CBD) is a compound found in the cannabis plant. Unlike its cousin tetrahydrocannabinol (THC), it's not psychoactive and doesn't cause a "high." CBD is often used for its potential therapeutic properties, including relief from discomfort, anxiety, and inflammation.

How does CBD work in the body?

CBD interacts with the body's endocannabinoid system (ECS), a complex cell-signaling system that plays a role in regulating a wide array of functions and processes, including sleep, mood, appetite, and immune response. By influencing the activity of various receptors and enzymes, CBD can affect the ECS and, in turn, potentially influence these bodily functions.

What is Metformin?

Metformin is a medication used primarily to treat Type 2 diabetes. It is sold under several brand names, including Glucophage, Metformin-ratiopharm, and Metformax. It helps to control high blood sugar and prevent complications such as kidney damage, blindness, nerve problems, and loss of limbs.

How does Metformin work in the body?

Metformin works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. It also improves your body's response to insulin, thereby helping to control blood sugar levels.

Potential Interactions between CBD and Metformin

Now that we understand what CBD and Metformin are, let's explore their potential interactions.

Both CBD and Metformin are processed by the body using the cytochrome P450 enzyme system in the liver. This system is responsible for metabolizing potentially toxic compounds, including over 60% of any drugs you have consumed. When CBD is consumed, it can inhibit the P450 system's ability to metabolize certain drugs, leading to an overall increase in processing times and higher levels of the drug in your system at one time.

Therefore, taking CBD and Metformin concurrently could potentially increase the effects and side effects of Metformin. This could lead to a higher risk of Metformin-related side effects, such as upset stomach, nausea, and low blood sugar.

Consulting Your Doctor

It is important to note that while the potential for an interaction exists, it does not mean it will necessarily occur. Everyone's body reacts differently to medications and supplements. Therefore, if you are considering taking CBD while on Metformin, it is essential to consult with your healthcare provider first. They can monitor your medication levels and adjust your dosage as necessary to avoid any potential interactions.


In conclusion, while CBD and Metformin both have potential health benefits, they are processed similarly in the body and could potentially interact. This interaction could lead to increased effects and side effects of Metformin. Therefore, it is crucial to consult with your healthcare provider before starting CBD if you are currently taking Metformin. While the potential for interaction exists, it does not mean it will necessarily occur, and your doctor can help you navigate this potential risk.

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