CBD and Metamizole (e.g. Novalgin, Novaminsulfon, Nolotil)

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Understanding CBD and Metamizole

Before delving into the potential interactions between Cannabidiol (CBD) and Metamizole, it's crucial to understand what these substances are and how they function in the body.

What is CBD?

CBD is a natural compound found in the Cannabis sativa plant. It has gained popularity due to its potential therapeutic effects, which include pain relief, anxiety reduction, and sleep improvement. Unlike its cousin compound, THC, CBD does not produce a "high" or psychoactive effect. It works by interacting with the body's endocannabinoid system, a complex network of receptors that regulates various physiological processes such as mood, sleep, and pain.

What is Metamizole?

Metamizole, also known as Dipyrone, is a non-opioid analgesic and antipyretic medication. It's commonly used to treat severe pain and fever. In the United States, Metamizole is not available due to its potential risk for causing agranulocytosis, a serious blood disorder. However, it's widely used in other parts of the world under various brand names like Novalgin, Novaminsulfon, and Nolotil. Metamizole works by inhibiting the production of certain chemicals in the body that cause inflammation and pain.

Potential Interactions between CBD and Metamizole

As with any combination of substances, there's potential for interaction between CBD and Metamizole. Both CBD and Metamizole are metabolized in the liver by the same group of enzymes, known as the cytochrome P450 (CYP450) system. This shared pathway could potentially lead to drug-drug interactions.

Effects of CBD on Metamizole

CBD has been found to inhibit the activity of some CYP450 enzymes. This means that if you're taking Metamizole and CBD together, CBD could slow down the metabolism of Metamizole, leading to higher levels of it in your bloodstream. This could enhance the effects and side effects of Metamizole.

Effects of Metamizole on CBD

Similarly, Metamizole may also affect the metabolism of CBD. However, more research is needed to understand the full extent of this interaction.

Consultation with Healthcare Professionals

Given the potential interactions between CBD and Metamizole, it's crucial to consult with a healthcare professional before starting CBD, especially if you're already on Metamizole or any other medication. A healthcare professional can provide personalized advice based on your health history and current medications.


While CBD and Metamizole both have potential therapeutic benefits, their interaction could potentially lead to enhanced effects and side effects. Therefore, it's essential to consult with a healthcare professional before combining these substances. As always, it's important to use any medication, including CBD, responsibly and under the guidance of a healthcare professional.

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