CBD and Lisinopril (e.g. Zestril, Prinivil, Lisodura)

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Understanding CBD and Lisinopril

With the growing popularity of Cannabidiol (CBD) as a natural remedy for various conditions, many are curious about its potential interaction with their current medications. In this article, we will delve into the interaction between CBD and Lisinopril, a common drug used to treat high blood pressure and heart conditions.

What is Lisinopril?

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that is commonly prescribed for the treatment of high blood pressure and heart failure. It is sold under various brand names worldwide, such as Zestril, Prinivil, and Lisodura. The drug works by relaxing blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently.

What is CBD?

Cannabidiol (CBD) is a natural compound found in the cannabis plant. Unlike its cousin THC, CBD does not have psychoactive properties, meaning it does not produce a "high." Instead, it is often used for its potential therapeutic benefits, which may include pain relief, anxiety reduction, and sleep improvement. CBD works by interacting with the body's endocannabinoid system (ECS), a complex cell-signaling system that plays a key role in regulating a range of functions and processes, including sleep, mood, appetite, and immune response.

Interactions Between CBD and Lisinopril

While there is currently limited research on the interaction between CBD and Lisinopril, it's important to understand that CBD can potentially interact with a wide range of medications. This is because CBD is metabolized in the body by the same group of liver enzymes - cytochrome P450 - that metabolizes many other drugs, including Lisinopril.

When CBD is taken concurrently with other medications, it can inhibit the function of these enzymes, leading to slower than normal breakdown of those medications. This can potentially increase the levels of these drugs in your system, which may increase side effects or intensify the effects of the medication.

Known Side Effects and Risks

Common side effects of Lisinopril include dizziness, lightheadedness, tiredness, or headache as your body adjusts to the medication. If CBD increases the concentration of Lisinopril in the blood, these side effects could potentially be exacerbated.

Similarly, while CBD is generally considered safe, it can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness, and fatigue. CBD can also interact with other medications, leading to an increase in their side effects.

Consulting a Healthcare Provider

Given the potential for interaction, it is crucial to consult with a healthcare provider before starting CBD if you are currently taking Lisinopril or any other medication. Your healthcare provider can provide personalized advice based on your current health status and medication regimen.


While CBD has potential therapeutic benefits, it is not without risks, especially when taken in conjunction with other medications like Lisinopril. Due to the potential for increased side effects and interactions, it is crucial to consult with a healthcare provider before adding CBD to your current medication regimen.

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