CBD and Levothyroxine (e.g. Eltroxin, Eutirox, Levoxyl, L-thyroxine, Thyrox)

medication pills

Understanding CBD and Levothyroxine

As the use of cannabidiol (CBD) becomes more widespread, many individuals who are currently on medications such as levothyroxine are considering incorporating CBD into their health regimen. Levothyroxine, a synthetic form of the thyroid hormone thyroxine, is commonly prescribed under several brand names including Eltroxin, Eutirox, Levoxyl, L-thyroxine, and Thyrox, depending on the region of the world. Given the potential for drug interactions, it's crucial to understand the possible effects of combining these substances. However, always consult with a healthcare professional before adding CBD to your current medications.

How CBD Works in the Body

CBD is a naturally occurring compound found in the cannabis plant. Unlike its cousin, delta-9-tetrahydrocannabinol (THC), CBD is not psychoactive. It works by interacting with the body's endocannabinoid system (ECS), a complex cell-signaling system that plays a role in regulating a range of functions and processes, including sleep, mood, appetite, and inflammation.

How Levothyroxine Works in the Body

Levothyroxine is a medication used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough thyroid hormones. It works by replacing or providing more thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery. Having enough thyroid hormone helps maintain normal mental and physical activity.

Potential Interactions between CBD and Levothyroxine

Research into the interactions between CBD and other medications is still in its early stages. However, some studies suggest that CBD may interfere with the way our bodies metabolize certain drugs, including levothyroxine, in the liver. This is because CBD can inhibit the enzyme system known as cytochrome P450, which is responsible for metabolizing many medications. If this system is inhibited, levothyroxine may not be metabolized as effectively, potentially leading to an increased concentration in the body.

Side Effects and Risks

While CBD is generally well-tolerated, it may cause side effects in some people, including fatigue, diarrhea, changes in appetite, and weight gain or loss. When combined with levothyroxine, the effects of both substances may be amplified. This could potentially lead to increased side effects or complications, such as heart palpitations, nervousness, or changes in weight. Additionally, due to the potential for increased concentration of levothyroxine in the body, there may be an increased risk of overmedication, which could lead to symptoms of hyperthyroidism.


In conclusion, while CBD has many potential health benefits, it's crucial to consider possible interactions with other medications, such as levothyroxine. The combination of CBD and levothyroxine may interfere with the metabolism of the medication, potentially leading to increased side effects or complications. Therefore, it's essential to consult with a healthcare professional before incorporating CBD into your health regimen if you're currently taking levothyroxine. Remember, your health and safety should always be the priority.

Back to blog

Leave a comment

Please note, comments need to be approved before they are published.