CBD and Ibuprofen (e.g. Advil, Motrin, Nurofen, Ibu-ratiopharm, Dolormin)

medication pills

Understanding CBD and Ibuprofen Interactions

As the popularity of Cannabidiol (CBD) continues to rise, many people who are currently on medications, such as Ibuprofen, are considering incorporating CBD into their health regimen. It's crucial to understand the potential interactions and side effects that could occur when combining these substances. This article aims to provide an impartial and clear understanding of the subject.

Common Brand Names for Ibuprofen

Ibuprofen is a well-known non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It's available over the counter in many parts of the world and is sold under various brand names. Here are some of the most common ones:

  • Advil and Motrin (USA)
  • Nurofen (UK, Australia, New Zealand)
  • Ibu-ratiopharm (Germany)
  • Dolormin (Germany)

How CBD and Ibuprofen Work in the Body

CBD, a compound found in the Cannabis Sativa plant, interacts with the body's endocannabinoid system, a complex biological system involved in maintaining certain aspects of your health. Early research suggests that CBD may help with pain, inflammation, and other conditions, but more studies are needed to confirm these findings.

On the other hand, Ibuprofen works by inhibiting enzymes called COX-1 and COX-2. These enzymes produce prostaglandins, substances that our body releases in response to illness and injury. Prostaglandins cause pain and inflammation, so by blocking them, ibuprofen helps to alleviate these symptoms.

Potential Interactions between CBD and Ibuprofen

It's important to note that CBD can interact with a variety of medications, including ibuprofen. Both CBD and ibuprofen are metabolized by the body using the same group of liver enzymes - called cytochrome P450. When these two substances are taken together, CBD can inhibit the body's ability to metabolize ibuprofen, leading to an accumulation of the drug in the body. This can potentially increase the risk of side effects.

These side effects may include:

  • Stomach pain, ulcers, or bleeding
  • High blood pressure
  • Fluid retention (causing swelling, such as around the lower legs, ankles, feet, or hands)
  • Kidney problems
  • Heart problems

However, it's important to mention that research on this topic is still in the early stages, and more studies are needed to fully understand the potential interactions between CBD and ibuprofen.

Consult a Doctor Before Combining CBD with Medications

While the information provided above is based on current research, it's always best to consult with a healthcare provider before starting any new treatment or supplement, including CBD, especially if you are currently taking other medications. A healthcare provider will be able to provide personalized advice based on your current health status and medication regimen.


In conclusion, while CBD holds promise for its potential health benefits, it's important to proceed with caution when considering combining it with medications like ibuprofen. Due to the shared metabolic pathway, there is a potential risk of increased side effects. Always consult with a healthcare provider before starting any new supplement regimen, especially if you are currently on medication.

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