CBD and Amphetamine (e.g. Adderall, Adderall XR)

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Understanding CBD and Amphetamines

When considering the use of Cannabidiol (CBD), it is important to understand how it might interact with any current medications you may be taking. In this article, we will explore the potential interactions between CBD and amphetamines, specifically Adderall and Adderall XR. These are two of the most commonly prescribed amphetamines in the United States for conditions such as Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy.

What is CBD?

CBD is a naturally occurring compound found in the Cannabis sativa plant. It has gained popularity in recent years for its potential therapeutic benefits, which may include pain relief, reducing anxiety, and improving sleep. Unlike its cousin, delta-9-tetrahydrocannabinol (THC), CBD does not produce a "high" or psychoactive effect.

How Does CBD Work in the Body?

CBD works by interacting with the body's endocannabinoid system (ECS). The ECS is involved in regulating a variety of functions including sleep, appetite, pain and immune system response. CBD can impact the activity of the ECS by interacting with the cannabinoid receptors in the body, potentially offering therapeutic benefits.

What are Adderall and Adderall XR?

Adderall and Adderall XR are brand names for a medication that contains two amphetamines: amphetamine aspartate monohydrate and amphetamine sulfate. These drugs are most commonly prescribed in the United States, but they are also known under different brand names in other parts of the world. For instance, in Canada, they are known as Dexedrine and Vyvanse, while in the UK, they are referred to as Elvanse and Tentin.

How Do Adderall and Adderall XR Work in the Body?

Adderall and Adderall XR work by increasing the levels of certain chemicals in the brain that help with concentration and focus. They stimulate the release of neurotransmitters such as dopamine and norepinephrine, which can help improve symptoms of ADHD and narcolepsy.

Potential Interactions Between CBD and Adderall/Adderall XR

While research on the interactions between CBD and amphetamines is limited, some studies suggest that CBD may affect the way your body metabolizes certain drugs, including amphetamines. This is because CBD can inhibit an enzyme called cytochrome P450, which is responsible for breaking down many drugs in the body. If this enzyme is inhibited, it could potentially lead to higher levels of amphetamines in the body, increasing the risk of side effects.

It's also worth noting that both CBD and amphetamines can have side effects of their own. CBD may cause fatigue, diarrhea, changes in appetite and weight, while amphetamines can cause increased heart rate, high blood pressure, and anxiety. Combining these two substances may potentially exacerbate these side effects.

Consulting with a Healthcare Professional

Before starting or changing any medication regimen, including the addition of CBD, it is crucial to consult with a healthcare professional. They can provide personalized advice based on your current medications, health status, and specific needs.


In summary, while CBD has potential therapeutic benefits, its interaction with amphetamines like Adderall and Adderall XR is not fully understood and could potentially lead to increased side effects. Therefore, it's essential to consult with a healthcare professional before combining these substances. As always, it's important to use any medication, including CBD, as directed by a healthcare provider to ensure safety and efficacy.

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