Cannabichromene or CBC a phytocannabinoid found in the cannabis plant. A relatively rare and non-psychoactive one like CBD.
Some cannabis enthusiasts say that CBC is the next best alternative to CBD. But still, further research is needed to prove its pharmacological properties.
The history and culture of the cannabis plant date back to a thousand years cultivated for a myriad of purposes.
In my opinion, I suppose our forefathers made better use of this natural resource by utilizing it in all possible areas of life. That includes food and nutrition, medicines, textiles, building material, body care, and so on.
In particular, the massive development in science and technology has allowed us to study individual compounds of the plant that help to unfold its hidden therapeutic values.
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Research limitations have pushed Cannabichromene (CBC) behind the spotlight compared to its celebrated cousins CBD and THC.
Therefore, this article aims to articulate the little known facts about CBC. In my experience, researching and writing about individual cannabinoids has simplified the complexity at the same time, exemplified the value of the Cannabis plant.
CBC is the most abundant naturally occurring cannabinoid, along with THC, CBD, and CBN. According to studies, freshly harvested dry-type Cannabis material contains CBC. Moreover, it also states that marijuana strains from the USA possess ample CBC content.
With regard to its uses, effects, and actions little is known. This is contrary to the reports that speak about CBC’s abundant availability.
To further clarify this, another study points out the need for extensive investigations on the concentrations of CBC in certain strains.
This inference is the outcome of the classification of the plant. That ‘drug type’ marijuana predominantly possesses higher concentrations of CBC than CBD. While ‘fiber type’ marijuana contains higher concentrations of CBD than CBC.
In other words, this assortment clearly distinguishes that some strains have more psychotropic potent, and some have more fiber potent.
Is CBC Psychotropic?
As per available research, CBC is not psychotropic. It is not scheduled by the Convention on Psychotropic Substances.
The key reason behind the non-psychoactive nature of CBC is that it does not interact much with CB1 receptors but exhibits some interactions with CB2 receptors.
At the same time, it binds with other receptors such as TRPV1 and TRPA1 that deal with pain management.
Also, the effect of CBC when co-administered with THC augments. But there are no published reports to clarify CBC’s pharmacological properties.
And, Decarboxylation, Isomerization, and Oxidation are the reactions that are part of this modification process.
Furthermore, studies show that this process begins with cannabigerolic acid (CBGA) transforming into the acid forms. They are Cannabidiolic acid synthase (CBDA), Cannabichromene acid synthase (CBCA), and Tetrahydrocannabinolic acid synthase (THCA).
Moreover, these three enzymes play a role in the biosynthesis of more than 60 cannabinoids.
Properties of CBC
Results on the pharmacological properties of CBC are available from limited studies only.
Based on limited animal studies, CBC could exert anti-inflammatory, antimicrobial, analgesic, and antidepressant-like activities.
Another study highlights its properties that promote new cell growth that could apply to migraine-like conditions. CBC’s ability to produce astroglial cells shows promising scope in considering it for Alzheimer’s and dementia.
Similarly, its chemopreventive characteristics are linked to a variety of cancers.
CBC’s ability to reduce sebum production related to anti-acne conditions is highlighted by some studies.
However, it is good to recall that these results are based on rodent models or are still under the research stage.
- Phytocannabinoids have a role beyond the endocannabinoid system.
- In our understanding of the Big six cannabinoids, one key takeaway is that a small molecular structure difference could bring out diverse physiological effects.
- An in-depth study on phytocannabinoids could open new avenues in the analysis of therapeutic applications of the whole cannabis plant and its extracts.
- Growing conditions and extraction methods influence the proportion of every cannabinoid.
- Cannabis Sativa does not directly produce THC, CBD, CBG, or CBC. It is responsible for generating its acidic precursors, which are THCA, CBDA, and CBCA because Cannabis sativa extracts are non-psychoactive. Only with the process of decarboxylation, during smoking or baking processes that take place usually above 105°C, the acid transforms into pure forms.